SONORA

SONORA

Towards Safe, Optimized and persoNalized radiOlogy and RAdiotherapy procedures for pregnant patients

Project coordinator

Hrvoje Brkić, PhD, Faculty of medicine, J. J. Strossmayer University of Osijek and Faculty of dental medicine and health, Crkvena 21, Osijek, Croatia

Project objective and goals

A number of pregnant patients are undergoing diagnostic and therapeutic radiological procedures placing the unborn child at an increased risk due to the use of ionising radiation. The lacking knowledge and patients' anxiety can lead to unnecessary termination of pregnancy. EU BSS requires that when the pregnant patient undergoes medical exposure, special attention should be given to the justification and optimization of the procedure, considering both, the expectant individual and the unborn child.

The project research focuses on improving the accuracy of fetal doses estimation in diagnostic and interventional radiology (DIR) and radiotherapy (RT) to optimize process and improve benefit/risk communication with the patient.

This aims of the project are:

The project will result in a good practice guide to perform fetal dose estimation in pregnant or potentially pregnant patients undergoing radiology or radiotherapy procedures. Fetal dose and associated risk data will be considered and debated for their ethical aspects to increase the quality of risk-benefit communication with the patient.

WP0 - PROJECT MANAGEMENT (WP leader – FDMZ)
 
WP 1 - STATE OF THE ART: PRACTICES, METHODS AND TOOLS (WP leader – IRSN)
Participants:
Task 1.1: review of the available tools and methods used or recommended for fetal dose assessment in DIR (VIO, IRSN, MEFOS, FDMZ, DUH)
Task 1.2: survey of routine clinical practices for pregnant patient in DIR (VIO, IRSN, STUK, MEFOS, FDMZ, DUH)
Task 1.3: review of the methods used or recommended for fetal dose assessment in RT (IRSN, SCK-CEN, SKANDION,FDMZ)
Task 1.4: survey of routine clinical practices for pregnant patients in RT (IST-ULisboa, STUK, IRSN, SKANDION)
 
WP 2 - PERSONALIZED PREGNANT PATIENTS (WP leader – MEFOS)
Task 2.1. Library of computational phantoms of pregnant patient (MEFOS, FDMZ, UKG, IST, IRSN)
Task 2.2. Develop physical phantoms in each trimester (MEFOS, FDMZ, SCK-CEN, UKG, DUH)
 
WP3 - DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY PROCEDURES DURING PREGNANCY (WP leader -EEAE)
Task 3.1. Determining the fetal dose range in the most frequent DIR procedures using measurements on physical phantoms and MC simulations on computational phantoms (MEFOS, DUH, FDMZ, IST, IRSN, RBI, EEAE, VIO)
Task 3.2. Determining uncertainties and limitations of available methods and software for fetal dose assessment used in clinical practice (EEAE, DUH, MEFOS, FDMZ, IST, IRSN, VIO)
Task 3.3. DIR procedures’ optimization in terms of fetal dose (EEAE, DUH, MEFOS, FDMZ, VIO)
 
WP4 - RADIOTHERAPY DURING PREGNANCY (WP leader - SCK CEN)
Task 4.1. Fetal dose measurements during pregnancy breast radiotherapy (SCK CEN, NPI, MEFOS, IST, SURO, EEAE, RBI, SKANDION, IFJ, DCPT)
Task 4.2. Development of a personalized dosimetry tool for pregnancy proton therapy (DCPT, SKANDION)
Task 4.3. Imaging doses to fetus in breast radiotherapy (IST, STUK, IRSN)
 
WP5 - SOCIAL OUTREACH (WP leader – RBI).
Task 5.1: Project communication and dissemination (RBI, all partners)
Task 5.2: Ethics workshops (SCK CEN, IPL)
Task 5.3: Developing empirically grounded patient communication: (MEFOS, SCK CEN, IPL, FDMZ, VIO, IRSN

Project partners


Faculty of medicine
Faculty of dental medicine and health
Institute for Radiation Protection and Nuclear Safety
Belgian Nuclear Research Centre
Ruđer Bošković Institute
National Radiation Protection Institute
Croatia
Croatia
France
Belgium
Croatia
Czech Republic



Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa
Instituto Superior Técnico
Helsingin yliopisto (University of Helsinki)
Dubrava University Hospital
Ústav jaderné fyziky AV ČR, v. v. i. (Nuclear Physics Institute of the CAS)
Greek Atomic Energy Commission
Portugal
Portugal
Finland
Croatia
Czech Republic
Greece



Kommunalforbundet Avancerad Stralbehandling
Faculty of Science, University of Kragujevac
The Henryk Niewodniczański Institute of Nuclear Physics Polish Academy of Sciences
Danish Center for Particle Therapy, Aarhus University Hospital
Veneto Institute of Oncology IOV - IRCCS
Sweden
Serbia
Poland
Denmark
Italy

Project duration

Duration of the project is 48 months


Photos or schemas related to the topic of the project